A functional variant within the MMP3 gene does not associate with human range of motion

作者：Posthumus Michael^*; Raleigh Stuart M; Ribbans William J; Schwellnus Martin P; Collins Malcolm

来源：Journal of Science and Medicine in Sport, 2010, 13(6): 630-632.

DOI：10.1016/j.jsams.2010.01.006

• Stretching
• Flexibility
• Matrix metalloprotemase
• Association
• Polymorphism
• Genotype

A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component Furthermore, the COL5A1 BstUI RFLP has now been identified as the first gene variant to be associated with human ROM Interestingly this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy We sought to determine whether the MMP3 rs679620 variant was associated with ROM both as a single marker and as an interacting marker with the COL5A1 BstUI RFLP One hundred and twenty one participants were included in this study All participants were genotyped for the MMP3 rs679620 variant and performed passive straight leg raise (SLR) and sit and reach (SR) measurements There were no significant differences in left leg SLR (L SLR) right leg SLR (R SLR) or SR measurements between the genotype groups (L SLR, P=0 494, R-SLR, P=0 435, SR, P=0 266) Furthermore there was no evidence of an interaction between the COL5A1 BstUI R

• 出版日期2010-11