Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp Isolated from an Antarctic Marine Sediment

作者：Kim Dayoung; Lee Eun Ju; Lee Jihye; Leutou Alain S; Shin Yern Hyerk; Choi Bomi; Hwang Ji Sun; Hahn Dongyup; Choi Hyukjae; Chin Jungwook; Cho Sung Jin; Hong Yong Deog; Ko Jaeyoung; Seong Chi Nam; Maloney Katherine N; Oh Dong Chan; Yang Inho; Hwang Hayoung; Nam Sang Jip

来源：Marine Drugs, 2018, 16(4): 130.

DOI：10.3390/md16040130

• Streptomyces sp.
• cold water natural product
• marine natural product
• zizaane-type sesquiterpenoid

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

• 出版日期2018-4