Association Study of Gene LPP in Women with Polycystic Ovary Syndrome

作者：Zhang, Bo; Zhao, Han; Li, Tao; Gao, Xuan; Gao, Qin; Tang, Rong; Zhang, Jiangtao; Chen, Zi-Jiang^*

来源：PLos One, 2012, 7(10): e46370.

DOI：10.1371/journal.pone.0046370

• TYROSINE-PHOSPHATASE 1B
• INSULIN-RESISTANCE
• PHENOTYPE
• PREVALENCE
• OBESITY

Background: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS. @@@ Methods: Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method. @@@ Results: In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (P-meta = 1.89E-05, OR = 1.23), rs4449306 (P-meta = 3.0E-04, OR = 1.10), rs6782041 (P-meta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls. @@@ Conclusions: Our results suggest that LPP gene might be a novel candidate for PCOS.

• 出版日期2012-10-3
• 单位山东大学