NEUROPATHOLOGIC FEATURES OF ANTI-DIPEPTIDYL-PEPTIDASE-LIKE PROTEIN-6 ANTIBODY ENCEPHALITIS

作者:Stokin Gorazd B*; Popovic Mara; Gelpi Ellen; Kogoj Ales; Dalmau Josep; Graus Francesc
来源:Neurology, 2015, 84(4): 430-432.
DOI:10.1212/WNL.0000000000001183

摘要

The role of antibodies against neuronal surface and synaptic proteins, which identify a group of encephalitides that usually improve with immunotherapy,(1) is not fully understood and neuropathology may help elucidate the immune mechanism involved.(2,3) Recently, antibodies against dipeptidyl-peptidase-like protein-6 (DPPX), an auxiliary subunit of Kv4.2 potassium channels involved in signal transduction, were identified in 7 patients with encephalitis.(4,5) We report the neuropathologic features of a new patient.

  • 出版日期2015-1-27