Dynamic signaling for neural stem cell fate determination

作者：Wen Shu; Li Hong; Liu Jia^*

来源：Cell Adhesion & Migration, 2009, 3(1): 107-117.

DOI：10.4161/cam.3.1.7602

• neural stem cells
• cell fate determination
• signaling
• neurogenesis
• astrogenesis
• oligogenesis
• transcription factors
• epigenetics

Central nervous system (CNS) development starts from neural stem cells (NSCs) which ultimately give rise to the three major cell types (neurons, oligodendrocytes and astrocytes) of the CNS. NSCs are specified in space- and time-related fashions, becoming spatially heterogeneous and generating a progressively restricted repertoire of cell types. Mammalian NSCs produce different cell types at different time points during development under the influence of multiple signaling pathways. These pathways act in a dynamic web mode to determine the fate of NSCs via modulating the expression and activity of distinct set of transcription factors which in turn trigger the transcription of neural fate-associated genes. This review thus introduces the major signal pathways, transcription factors and their cross-talks and coordinative interactions in NSC fate determination.

• 出版日期2009-3
• 单位大连医科大学