AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

作者:Nakhi Ali; Archana Sivakumar; Seerapu Guru Pavan Kumar; Chennubhotla Keerthana Sarma; Kumar Kummari Lalith; Kulkarni Pushkar; Haldar Devyani; Pal Manojit*
来源:Chemical communications, 2013, 49(56): 6268-6270.
DOI:10.1039/c3cc42840k

摘要

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

  • 出版日期2013