Nonoparticles of biodegradable polymers for new-concept chemotherapy

作者：Feng SS^*

来源：Expert Review of Medical Devices, 2004, 1(1): 115-125.

DOI：10.1586/17434440.1.1.115

• anticancer drugs
• biomaterials
• blood-brain barrier
• cancer
• chemothetapeutic engineering
• controlled release
• drug delivery
• oral chemotherapy
• paclitaxel
• targeted delivery

The current regimen of chemotherapy is for from satisfactory - its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under Intensive Investigation In the past few decades In attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments In nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.

• 出版日期2004-9