Association between the AGTR1 polymorphism 1166A > C and serum levels of high-sensitivity C-reactive protein

作者：Suchankova Petra^*; Henningsson Susanne; Olsson Marie; Baghaei Fariba; Rosmond Roland; Holm Goran; Eriksson Elias; Ekman Agneta

来源：Regulatory Peptides, 2009, 152(1-3): 28-32.

DOI：10.1016/j.regpep.2008.11.001

• Angiotensin II (AngII)
• Angiotensin II type 1 receptor (AGTR1)
• High-sensitivity C-reactive protein (hsCRP)
• Inflammation
• Renin-angiotensin system (RAS)
• 1444C > T polymorphism
• 1166A > C polymorphism

Genetic factors have been shown to influence high-sensitivity C-reactive protein (hsCRP) levels. however, which genes that are involved in this process remains to be clarified. The renin-angiotensin system (RAS) is of importance for the regulation of inflammation, and blockade of angiotensin II type 1 receptors (AGTR1) influences hsCRP levels. These findings prompted us to investigate whether a polymorphism in the AGTR1 gene may influence hsCRP levels. Additionally, a polymorphism in the CRP gene that has previously been shown to influence hsCRP levels was genotyped. Serum levels of hsCRP were measured in 270 42-year-old women recruited from the population registry. Two single nucleotide polymorphisms were analysed: 1166A>C and 1444C>T of the AGTR1 and CRP gene, respectively. The A allele of the AGTR1 polymorphism 1166A>C was dose-dependently associated with higher hsCRP levels (p=0.014, adjusted for confounding factors and multiple comparisons). hsCRP levels were not significantly influenced by the CRP 1444C>T genotype; however, an interaction between the two studied polymorphisms with respect to hsCRP levels was observed (p=0.018). The significant association between the AGTR1 polymorphism and hsCRP levels, which appears to be independent of anthropometric and metabolic traits, is yet another indication of a direct influence of RAS on inflammation.

• 出版日期2009-1-8
• 单位河北医科大学