Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4(+) T cells

作者：Plesa Gabriela; Dai Jihong; Baytop Cliff; Riley James L; June Carl H; O'Doherty Una^*

来源：Journal of Virology, 2007, 81(24): 13938-13942.

DOI：10.1128/JVI.01745-07

Resting CD4(+) T cells restrict human immunodeficiency virus (HIV) infection at a step prior to integration. Despite this restriction, we showed previously that HIV integration occurs in resting CD4(+) T cells in vitro, albeit at lower levels than in activated CD4(+) T cells. Here we show that addition of deoxynucleosides enhanced integration and 2LTR formation in resting CD4(+) T cells but that the kinetics were still significantly delayed compared to those of activated T cells. Thus, deoxynucleoside addition partially overcomes the restriction to HIV infection in resting CD4(+) T cells.

• 出版日期2007-12