Potent antitumor activity of zoledronic acid-induced V gamma 9V delta 2 T cells against primary effusion lymphoma

作者：Goto Hirold; Matsuda Kould; Srikoon Pattaravadee; Kariya Ryusho; Hattori Shinichiro; Taura Manabu; Katano Harutaka; Okada Seiji^*

来源：Cancer Letters, 2013, 331(2): 174-182.

DOI：10.1016/j.canlet.2012.12.021

• AIDS
• Primary effusion lymphoma
• V gamma 9V delta 2 T cell
• Zoledronic acid

Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced V gamma 9V delta 2 T cells against PEL cells in vitro and in vivo. V gamma 9V delta 2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. V gamma 9V delta 2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced V gamma 9V delta 2 T cells could demonstrate an efficient strategy for PEL.

• 出版日期2013-5-1