Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos

作者：Noguchi Taka aki K; Ishimine Hisako; Nakajima Yoshiro; Watanabe Susaki Kanako; Shigeta Naoki; Yamakawa Norio; Wang Pi Chao; Asashima Makoto; Kurisaki Akira^*

来源：Gene Expression Patterns, 2012, 12(3-4): 154-163.

DOI：10.1016/j.gep.2012.01.001

• Gastrointestine
• Stomach
• Adra2a
• Fzd5
• Trpv6
• Barx1
• Mouse embryo
• Endoderm
• Mesenchyme
• Cell surface markers

The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes - Adra2a, Fzd5, and Trpv6 - that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.

• 出版日期2012-4