A novel organocatalytic multi-component reaction: an efficient synthesis of polysubstituted pyrano-fused spirooxindoles

作者：Tisseh Zeinab Noroozi; Ahmadi Fereshteh; Dabiri Minoo^*; Khavasi Hamid Reza; Bazgir Ayoob

来源：Tetrahedron Letters, 2012, 53(28): 3603-3606.

DOI：10.1016/j.tetlet.2012.05.019

• Spirooxindole
• Isatin
• Acetylenic ester
• Organocatalytic reaction

A practical, simple, and efficient method for the synthesis of pyrano-fused spirooxindoles via an organocatalytic three-component reaction of isatins, malononitrile, and dialkyl acetylenedicarboxylate in the presence of 3,4-dimethylaniline as an organocatalyst in ethanol is reported. The structures of these products are confirmed by IR, H-1 NMR and C-13 NMR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction studies.

• 出版日期2012-7-11