科研之友
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摘要
Background The prognosis for recurrent or refractory brain tumors in children is poor with conventional therapies Topotecan is a topoisomerase I inhibitor with good central nervous system (CNS) penetration following oral administration Increased efficacy of topotecan has been demonstrated with prolonged low dose daily treatment in pre clinical models To investigate further this drug delivered orally in pediatric CNS malignancies a phase II study in children with recurrent or refractory brain tumors was performed Procedure Patients <= 21 years of age at diagnosis with a recurrent progressive or refractory primary CNS malignancy and measurable disease, were eligible Patients enrolled into four strata ependymoma (N = 4), high grade glioma (HGG) (N = 6), brainstem glioma (BSG) (N = 13) and primitive neuroectodermal tumor (PNET) (N = 8) Oral topotecan was administered once daily at a dose of 0 8 mg/m(2)/day for 21 consecutive days repeated every 28 days Response and toxicity profiles were evaluated Results Twenty six patients were evaluable (median age 9 2 years 10 males) Two objective responses were observed in PNET patients with disseminated tumor at study entry These two patients remain alive and in remission 7 and 9 5 years off study Four other patients (two BSG, one PNET and one HGG) had stable disease (median 4 6 months) The most common toxicities were hemato logic Conclusions Daily oral topotecan at a dose of 0 8 mg/m(2)/day can be safely administered to children with recurrent or refractory brain tumors This regimen identified activity in recurrent PNE
- 出版日期2011-1
