Antioxidant and immunomodulatory activity of selenium exopolysaccharide produced by Lactococcus lactis subsp lactis

作者：Guo Yuxing; Pan Daodong^*; Li Hua; Sun Yangying; Zeng Xiaoqun; Yan Bingxiang

来源：Food Chemistry, 2013, 138(1): 84-89.

DOI：10.1016/j.foodchem.2012.10.029

• Selenium-exopolysaccharides
• Antioxidation activity
• Immunomodulatory activity
• Lactococcus lactis subsp lactis

Exopolysaccharide (EPS) was isolated and purified from Lactococcus lactis subsp. Lactis culture broth. Selenium chloride oxide (SeCl2O) was added to the EPS to synthesize selenium-exopolysaccharide (Se-EPS). The in vitro and in vivo antioxidant and in vivo immunomodulatory activity of EPS and Se-EPS were compared. EPS and Se-EPS scavenged superoxide anions and hydroxyl radicals. They also increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, while decreasing malondialdehyde (MDA) levels in serum and in the livers of mice. Se-EPS showed stronger in vitro and in vivo antioxidant activity than were shown by EPS. The in vivo immunoenhancement activity of EPS and Se-EPS induced by cyclophosphamide (CY) treatment in immunosuppressed mice was researched. EPS and Se-EPS treatments increased macrophage phagocytosis, spleen and thymus indices and haemolytic complement activity (HC50). Se-EPS showed stronger immunomodulatory activity than did EPS.

• 出版日期2013-5-1
• 单位南京师范大学; 宁波大学