科研之友
微信
新浪微博
Facebook
分享链接
摘要
Lewis acid catalyzed asymmetric allylation of N,O-acetal 7 with allyltrimethylsilane was developed for the synthesis of compounds 9, 10 and 16 with high disasterselectivities. A key middle compound 21 for synthesis of (-)-epiquinamide (1) was easily prepared from allylation product 16. In continuation of our work, a convenient method for synthesis of (+)-febrifugine (3) was also described from the mixture of (2S,3S) and (2S,3R)-9. Therefore, a possible approach for gram scale preparation of (+)-febrifugine (3) from glutamic acid was achieved.
