HNRNP-G - SEQUENCE AND CHARACTERIZATION OF A GLYCOSYLATED RNA-BINDING PROTEIN

作者：SOULARD M; DELL**ALLE V; SIOMI MC; PINOLROMA S; CODOGNO P; BAUVY C; BELLINI M; LACROIX JC; MONOD G; DREYFUSS G; LARSEN CJ

来源：Nucleic Acids Research, 1993, 21(18): 4210-4217.

DOI：10.1093/nar/21.18.4210

The autoantigen p43 is a nuclear protein initially identified with autoantibodies from dogs with a lupus-like syndrome. Here we show that p43 is an RNA-binding protein, and identify it as hnRNP G, a previously described component of heterogeneous nuclear ribonucleoprotein complexes. We demonstrate that p43/hnRNP G is glycosylated, and identify the modification as O-linked N-acetylglucosamine. A full-length cDNA clone for hnRNP G has been isolated and sequenced, and the predicted amino acid sequence for hnRNP G shows that it contains one RNP-consensus RNA binding domain (RBD) at the amino terminus and a carboxyl domain rich in serines, arginines and glycines. The RBD of human hnRNP G shows striking similarities with the RBDs of several plant RNA-binding proteins.

• 出版日期1993-9-11