Design, synthesis and antifungal activity of novel triazole derivatives

作者：Sheng CQ^*; Zhang WN; Ji HT; Song YL; Zhang M; Zhou YJ; Lu JG; Zhu J

来源：Chinese Chemical Letters, 2004, 15(4): 404-407.

• antifungal
• triazole
• synthesis

Twenty-one 1-(1H-1,2,4-triazolyl)-2-(2,4-diflurophenyl)-3-(4-substituted-1-piperazi nyl) -2-propanol derivatives were designed and synthesized, on the basis of the active site of lanosterol 14alpha-demethylase. In vitro antifungal activities showed that some of the target compounds had higher antifangal activity and broader antifungal spectrum than fluconazole.

• 出版日期2004-4
• 单位中国人民解放军第二军医大学