Molecular Epidemiology of Rabies in Southern People's Republic of China

作者：Tao, Xiao Yan; Tang, Qing^*; Li, Hao; Mo, Zhao Jun; Zhang, Hong; Wang, Ding Ming; Zhang, Qiang; Song, Miao; Velasco Villa, Andres; Wu, Xianfu; Rupprecht, Charles E; Liang, Guo Dong

来源：Emerging Infectious Diseases, 2009, 15(8): 1192-1198.

DOI：10.3201/eid1508.081551

In recent years, the number of human rabies cases in the People's Republic of China has increased during severe epidemics in 3 southern provinces (Guizhou, Guangxi, and Hunan). To analyze the causes of the high incidence of human rabies in this region, during 2005-2007, we collected 2,887 brain specimens from apparently healthy domestic dogs used for meat consumption in restaurants, 4 specimens from suspected rabid dogs, and 3 from humans with rabies in the 3 provinces. Partial nucleoprotein gene sequences were obtained from rabies-positive specimens. Phylogenetic relationships and distribution of viruses were determined. We infer that the spread of rabies viruses from high-incidence regions, particularly by long-distance movement or transprovincial translocation of dogs caused by human-related activities, may be 1 cause of the recent massive human rabies epidemics in southern China.

• 出版日期2009-8
• 单位广西壮族自治区疾病预防控制中心; 贵州省疾病预防控制中心; 中国疾病预防控制中心病毒病预防控制所; 中国疾病预防控制中心