Drug release from layered double hydroxides and from their polylactic acid (PLA) nanocomposites

作者：San Roman Maria S; Holgado Maria J; Salinas Beatriz; Rives Vicente^*

来源：Applied Clay Science, 2013, 71: 1-7.

DOI：10.1016/j.day.2012.10.014

• Drug release
• Polylactic acid
• Nanocomposites
• Layered double hydroxides

Layered double hydroxides (LDH) with intercalated diclofenac, chloramphenicol and ketoprofen have been supported and dispersed in semicrystalline polylactic acid (PLA). The solids have been characterized by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and Fourier-Transform infrared spectroscopy (FT-IR). Drug release from the systems prepared was followed by UV-vis spectroscopy. Release is almost complete after 24 h for ketoprofen from the drug-LDH systems, but lower values were measured for the other drugs (60 and 80%, respectively, for diclofenac and chloramphenicol); however, when supported on PLA the release was much slower and could be related to the degradation of the polymer.

• 出版日期2013-1