Evaluation of Interleukin 1汕 in Febrile Convulsion

作者：Fatemeh Behmanesh; Farah Ashrafzadeh; Abdoreza Varasteh; Abdoreza Shakeri

来源：Iranian Journal of Allergy, Asthma and Immunology, 2012.

• Children
• Febrile convulsion
• Interleukin 1$

We aimed to study the MnTnHex-2-PyP effect on some markers of lung antioxidant defence system in mice asthma model.The study was carried out on 28 C57B1/6 mice divided into four treatment groups: group 1 每 controls; group 2 每 injected and inhaled with ovalbumin; group 3 每 treated with MnTnHex-2-PyP and inhaled with phosphate buffered saline; group 4 每 injected with ovalbumin and MnTnHex-2-PyP but also inhaled with ovalbumin. On days 24, 25 and 26, mice from groups 1 and 2 were inhaled with PBS for 30 min, and those from groups 2 and 4 were given a 1% ovalbumin solution. One hour before inhalation, and 12 hours later the animals from groups 1 and 2 were injected i.p. with 100 米l PBS, and those from groups 3 and 4 received a 100 米l MnTnHex-2-PyP solution in PBS, 扼ontaining 0,05mg/kg. The animals were killed by exsanguination 48 hours after the last inhalation for obtaining a lung homogenate.The activities of superoxide dismutase, catalase, glutathione peroxidase and the non-protein sulphhydryl group content in the lung homogenate were investigated. Ovalbumin decreased the activities of superoxide dismutase (p=0.01), catalase (p=0.002), glutathione peroxidase and non-protein sulphhydryl groups content (p%26lt;0.001) in comparison to controls. In group 4 (ovalbumin and MnTnHex-2-PyP) the activities of superoxide dismutase (p=0.044), catalase (p=0.045), glutathione peroxidase (p=0.002), and the non-protein sulphhydryl groups content (p%26lt;0.001) were significantly increased compared to ovalbumin (group 2).MnTnHex-2-PyP restored the activities of basic enzymes in the lung antioxidant defence system in ovalbumin-induced asthma mice model, 48 hours after the last nebulization.

• 出版日期2012