A nested phosphorus and proton coil array for brain magnetic resonance imaging and spectroscopy

作者：Brown Ryan^*; Lakshmanan Karthik; Madelin Guillaume; Parasoglou Prodromos

来源：NeuroImage, 2016, 124: 602-611.

DOI：10.1016/j.neuroimage.2015.08.066

• Dual-tuned coil
• Transceive phased array
• Degenerate birdcage
• Creatine kinase reaction
• FLORET pulse sequence

A dual-nuclei radiofrequency coil array was constructed for phosphorus and protonmagnetic resonance imaging and spectroscopy of the human brain at 7 T. An eight-channel transceive degenerate birdcage phosphorus module was implemented to provide whole-brain coverage and significant sensitivity improvement over a standard dual-tuned loop coil. A nested eight-channel proton module provided adequate sensitivity for anatomical localization without substantially sacrificing performance on the phosphorus module. The developed array enabled phosphorus spectroscopy, a saturation transfer technique to calculate the global creatine kinase forward reaction rate, and single-metabolite whole-brain imaging with 1.4 cm nominal isotropic resolution in 15 min (2.3 cm actual resolution), while additionally enabling 1 mm isotropic proton imaging. This study demonstrates that a multi-channel array can be utilized for phosphorus and proton applications with improved coverage and/or sensitivity over traditional single-channel coils. The efficient multi-channel coil array, time-efficient pulse sequences, and the enhanced signal strength available at ultra-high fields can be combined to allow volumetric assessment of the brain and could provide new insights into the underlying energy metabolism impairment in several neurodegenerative conditions, such as Alzheimer's and Parkinson's diseases, as well as mental disorders such as schizophrenia.

• 出版日期2016-1-1