A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

作者:Han QB; Yang L; Wang YL; Qiao CF; Song JZ; Sun HD; Xu HX*
来源:Chemistry and Biodiversity, 2006, 3(1): 101-105.
DOI:10.1002/cbdv.200690000

摘要

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcillia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).