Nuclear pore complex-a coat specifically tailored for the nuclear envelope

作者：Onischenko Evgeny; Weis Karsten^*

来源：Current Opinion in Cell Biology, 2011, 23(3): 293-301.

DOI：10.1016/j.ceb.2011.01.002

Nuclear pore complexes (NPCs) are highly selective transport gates that enable the bi-directional traffic of macromolecules across the nuclear envelope (NE). NPCs are located at the fusion pores between the inner and outer membranes of the NE and are built from a common set of similar to 30 different proteins, nucleoporins. Remarkably, recent proteomic, bioinformatic, and structural studies have provided firm evidence that key structural nucleoporins share common ancestry with elements of coated vesicles, indicating an evolutionary link between these structures. This has provided novel insight into the origin of NPCs and may help us to better functionally characterize these fundamental components of eukaryotic cells.

• 出版日期2011-6