Neurological manifestations, laboratory and neuroimaging features in HIV-infected patients

作者：Chen, Hai; Lin, Fangju; Liu, Shimeng; Da, Yuwei; Guo, Dongmei^*

来源：Neurosciences, 2017, 22(4): 311-315.

DOI：10.17712/nsj.2017.4.20160606

• PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
• AIDS DEMENTIA COMPLEX
• NEUROCOGNITIVE DISORDERS
• NEUROMYELITIS-OPTICA
• MULTIPLE-SCLEROSIS
• THYROIDITIS

Objectives: To present detailed information regarding these aspects in Human Immunodeficiency Virus (HIV)-infected patients making an effort to improve the recognition of neurological complications of HIV infection. @@@ Methods: This retrospective study analyzed the clinical manifestations, laboratory and neuroimaging results of HIV-infected patients with neurological complications at Xuanwu hospital, Beijing, China from January 2011 to December 2014, one of top-rated hospitals in Beijing, China. @@@ Results: A diverse range of clinical diagnoses was identified, including encephalopathy, meningoencephalitis, peripheral neuropathy, multiple sclerosis, cerebral infarction and lymphoma associated with HIV infection. The mostly observed neurological disorders were motor/sensory deficits in the limbs (75%), cognitive impairments (42%) and fever (33%). Non-specific results of laboratory tests, including elevated erythrocyte sedimentation rate (ESR), cerebrospinal fluid (CSF) protein concentration and IgG, were found. Brain Magnetic Resonance Imaging (MRI) abnormalities displayed a variety of patterns and distributions due to diverse clinical profiles. @@@ Conclusion: The clinical scenarios of HIV-infected patients are remarkably diverse and complex. Etiological tests would be cardinal to make more definitive diagnosis for HIV-infected patients. Prospective studies with follow-up were needed to bring more accurate information.

• 出版日期2017-10
• 单位北京市石景山医院; 首都医科大学