科研之友
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摘要
The rhodium-catalyzed asymmetric hydrogenation of various, beta-dehydroamino acid derivatives to give optically active,beta-amino acids has been examined. Chiral monodentate 4,5-dihydro-3H-dinaphthophosphepines, which are easily tuned and accessible in a multi-10-g scale, have been used as ligands. The enantioselectivity is largely dependent on the nature of the substituent at the phosphorous atom and on the structure of the substrate. Applying optimized conditions up to 94% ee was achieved.
- 出版日期2007-6
