11-hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum

作者：Sappapan Ruengrit; Sommit Damrong; Ngamrojanavanich Nattaya; Pengpreecha Somchai; Wiyakrutta Suthep; Sriubolmas Nongluksna^*; Pudhom Khanitha

来源：Journal of Natural Products, 2008, 71(9): 1657-1659.

DOI：10.1021/np8004024

A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from Cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonoccrin (2) displayed activity against Plasmodium falciparum (K 1, multidrug-resistant strain) with IC(50) values of 0.68 and 7.70 mu M, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.

• 出版日期2008-9