A cross-coupling synthesis of functionalised biaryls using Knochel-type organozinc reagents and a pyridine enhanced palladium catalyst

作者：Wang, Min; Liu, Fang; Zeng, Meng-Tian; Xu, Wan; Liu, Min; Dong, Zhi-Bing^*

来源：Journal of Chemical Research, 2016, 40(6): 382-384.

DOI：10.3184/174751916X14636735575269

• preparation
• biaryls
• PEPPSI
• Negishi reaction
• organozinc reagents

A variety of functionalised biaryls were synthesised on the 20-30 mmol scale by using Knochel type organozinc reagents (organozinc reagents prepared from aryl halides, Zn powder and LiCl) catalysed by PEPPSI (a pyridine enhanced palladium catalyst). The protocol enabled the Negishi reactions to proceed in a smooth, rapid and mild way to give the corresponding products in excellent yields (80 similar to 96%). Sensitive functional groups, such as CN and COOEt groups, were tolerated in the coupling reaction.

• 出版日期2016-6
• 单位武汉工程大学