Network modeling to identify new mechanisms and therapeutic targets for Parkinson%26apos;s disease

作者：MacArthur Linda; Ressom Habtom; Shah Salim; Federoff Howard J^*

来源：Expert Review of Neurotherapeutics, 2013, 13(6): 685-693.

DOI：10.1586/ERN.13.59

• drug discovery
• genome-wide association study
• network modeling
• neurodegeneration
• Parkinson%26apos
• s disease

Biomolecules in subnetworks are the focus of a new strategy to develop drugs that halt complex diseases. In this article, the authors use genome-wide association study and linkage data derived from Parkinson%26apos;s disease studies to illustrate how algorithms that use gene and protein interaction databases reveal subnetworks in biological systems that suggest mechanisms for disease progression. Network modeling may help develop testable hypotheses for neurodegenerative diseases and open up new avenues for therapeutic development.

• 出版日期2013-6