alpha 2-Macroglobulin Inhibits the Malignant Properties of Astrocytoma Cells by Impeding beta-Catenin Signaling

作者：Lindner Inge; Hemdan Nasr Y A; Buchold Martin; Huse Klaus; Bigl Marina; Oerlecke Ilka; Ricken Albert; Gaunitz Frank; Sack Ulrich; Naumann Andreas; Hollborn Margrit; Thal Dietmar; Gebhardt Rolf; Birkenmeier Gerd^*

来源：Cancer Research, 2010, 70(1): 277-287.

DOI：10.1158/0008-5472.CAN-09-1462

Targets that could improve the treatment of brain tumors remain important to define. This study of a transformation-associated isoform of alpha 2-macroglobulin (A2M*) and its interaction with the low-density lipoprotein receptor-related protein-1 (LRP1) suggests a new mechanism for abrogating the malignant potential of astrocytoma cells. LRP1 bound A2M* found to be associated with an inhibition of tumor cell proliferation, migration, invasion, spheroid formation, and anchorage-independent growth. Transcriptional studies implicated effects on the Wnt/beta-catenin signaling pathway. Notably, LRP1 antibodies could phenocopy the effects of A2M*. Our findings suggest a pathway of tumor suppression in astrocytoma that might be tractable to therapeutic exploitation. Cancer Res; 70(1); 277-87.

• 出版日期2010-1-1