A facile cyanoacetylation of indoles with cyanocetic acid and propionic anhydride

作者：Venkatanarayana M^*; Dubey P K

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2013, 52(6): 810-813.

• Indole
• cyanoacetic acid
• propionic anhydride
• electrophilic aromatic substitution
• acylations

A facile method for the synthesis of 3-cyanoacetyl indole derivatives mediated by propionic anhydride is described. These 3-cyanoacetylindole derivatives have been used in a starting material for the syntheses of various new compounds like (E)-2-((1H-indol-3-yl)methylene)-3-oxoindolylnitrile, 3-acetylcoumrineindoles, 3-cyanoacetylquinones, 3-cyanoacetylindolyl chalcones, E-2-benzyl-3-(1H-indol-3yl)acrylonitriles, 3-(1H-indol-3-yl)-3-oxopropanamides and 3-acetylindoles.

• 出版日期2013-6