1,4-Disubstituted 1,2,3-Triazole- and 1,5-Disubstituted 1,2,3-Triazole-based Bis-Sulfonamides in Selective Fluorescence Sensing of ATP

作者：Dey Santu; Sarkar Tanmay; Majumdar Anupam; Pathak Tanmaya^*; Ghosh Kumaresh^*

来源：ChemistrySelect, 2017, 2(6): 2034-2038.

DOI：10.1002/slct.201601933

• ATP sensors
• 1,5-disubstituted
• 1,2,3-triazole
• fluorometric recognition
• host-guest complex
• 1,2,3-triazolebased thiourea

1,4-and 1,5-Disubstituted 1,2,3-triazole scaffolds as surrogate of amide with large dipole moment have been utilized to access two isomeric naphthylthiourea-based chemosensors 1 and 2 in appreciable overall yields. The easily synthesizable chemosensors 1 and 2 are designed to recognize anions and also to realize a comparative view on their sensing potentials. Different inorganic phosphates and a group of phosphorylated nucleosides such as ATP, ADP and AMP are selectively recognized by these chemosensors in semi aqueous system. The fluorometric study revealed that both the sensors sensed ATP selectively in CH3CN/H2O (4/1,v/v) by showing considerable increase in emission. 1,4-Disubstituted triazole-based sensor 1 has been established to be more effective than the 1,5disubstituted triazole-based sensor 2 in selective sensing of ATP.

• 出版日期2017-2