科研之友
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摘要
We present a novel methodology for the asymmetric synthesis of beta-mercaptolactones via isomerization of cohydroxy-alpha,beta-unsaturated thioesters by means of a bifunctional aminothiourea catalyst. The catalyst interacts with the substrate through the cooperative action of both a covalent bond at the amino group and noncovalent bonding at the thiourea group. The potential for an enantiodivergent synthesis could also be demonstrated by carrying out the reaction in a different solvent system.
- 出版日期2014-4-18
