Nuclear Receptors in Pancreatic Tumor Cells

作者：Damaskos Christos^*; Karatzas Theodore; Kostakis Ioannis D; Nikolidakis Lampros; Kostakis Alkiviadis; Kouraklis Gregory

来源：Anticancer Research, 2014, 34(12): 6897-6911.

• Pancreatic cancer
• nuclear receptors
• growth factors
• tumor cells

Aim: This review focuses on nuclear receptors expressed in pancreatic cancer. Materials and Methods: An extensive search of articles published up to March 2013 was conducted using the MEDLINE database. The key words used were %26quot;pancreatic cancer%26quot;, %26quot;molecular receptors%26quot; and %26quot;growth factors%26quot;. A total of 112 articles referred to pancreatic cancer, molecular receptors and/or growth factors were included. Results: Receptors of growth factors, such as the epithelial growth factor receptor, insulin-like growth factor-1 receptor, vascular endothelial growth factor receptor and others, such as integrin alpha 5 beta 1, somatostatin receptors, the death receptor 5, claudin, notch receptors, mesothelin receptors, follicle-stimulating hormone receptors, the MUC1 receptor, the adrenomedullin receptor, the farnesoid X receptor, the transferrin receptor, sigma-2 receptors, the chemokine receptor CXCR4, the urokinase plasminogen activator receptor, the ephrine A2 receptor, the GR1A3 receptor, the RON receptor and the angiotensin II receptor AT-1 are expressed in pancreatic tumor cells. These molecules are implicated in tumor growth, apoptosis, angiogenesis, metastasis etc. Conclusion: After identifying the molecular receptors associated with the pancreatic cancer, many more target molecules playing important roles in tumor pathophysiology and senescence-associated signal transduction in cancer cells will be identified. This may have a significant influence on diagnosis, therapy and prognosis of pancreatic cancer.

• 出版日期2014-12