An efficient oxa-Michael addition to diethyl vinylphosphonate under mild reaction conditions

作者:Baszczynski Ondrej*; Jansa Petr; Dracinsky Martin; Kaiser Martin Maxmilian; Spacek Petr; Janeba Zlatko
来源:RSC Advances, 2012, 2(4): 1282-1284.
DOI:10.1039/c2ra00938b

摘要

An oxa-Michael addition of various secondary and branched primary alcohols to diethyl vinylphosphonate was systematically studied and optimized. This efficient method precedes using of harsh reaction conditions (e.g. strong bases, high temperatures) and gains access to an important class of biologically active compounds in one step.

  • 出版日期2012