An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

作者：Yeung, Leo W. Y.; Taniyasu, Sachi; Kannan, Kurunthachalam; Xu, Della Z. Y.; Guruge, Keerthi S.; Lam, Paul K. S.; Yamashita, Nobuyoshi^*

来源：Journal of Chromatography A, 2009, 1216(25): 4950-4956.

DOI：10.1016/j.chroma.2009.04.070

• Whole blood
• Acetonitrile
• Solid phase extraction
• Formic acid
• Taurodeoxycholic acid
• Perfluorooctanesulfonate

A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX (R) solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences Such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals.

• 出版日期2009-6-19
• 单位香港城市大学