A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer

作者：Yerokun Babatunde A; Yang Chi Fu Jeffrey; Gulack Brian C; Li Xuechan; Mulvihill Michael S; Gu Lin; Wang Xiaofei; Harpole David H; D'Amico Thomas A; Berry Mark F; Hartwig Matthew G^*

来源：The Journal of Thoracic and Cardiovascular Surgery, 2017, 154(2): 675-+.

DOI：10.1016/j.jtcvs.2017.02.065

• sublobar resection
• wedge resection
• stereotactic body radiotherapy
• NSCLC
• lung cancer
• overall survival

Objective: Lobectomy is considered optimal therapy for early-stage non-small cell lung cancer, but sublobar wedge resection and stereotactic body radiation therapy are alternative treatments. This study compared outcomes between wedge resection and stereotactic body radiotherapy.
Methods: Overall survival of patients with cT1N0 and tumors <= 2 cm who underwent stereotactic body radiotherapy or wedge resection in the National Cancer Data Base from 2008 to 2011 was assessed via a Kaplan-Meier and propensity score-matched analysis. A center-level sensitivity analysis that used observed/expected mortality ratios was conducted to identify an association between center use of stereotactic body radiotherapy and mortality.
Results: Of the 6295 patients included, 1778 (28.2%) underwent stereotactic body radiotherapy, and 4517 (71.8%) underwent wedge resection. Stereotactic body radiotherapy was associated with significantly reduced 5-year survival compared with wedge resection in both unmatched analysis (30.9% vs 55.2%, P<.001) and after adjustment for covariates (31.0% vs 49.9%, P<.001). Stereotactic body radiotherapy also was associated with worse overall survival than wedge resection after 2 subgroup analyses of propensity-matched patients (P<.05 for both). Centers that used stereotactic body radiotherapy more often as opposed to surgery for patients with cT1N0 patients with tumors < 2 cm were more likely to have an observed/expected mortality ratio> 1 for 3-year mortality (P = .034).
Conclusions: In this national analysis, wedge resection was associated with better survival for stage IA non-small cell lung cancer than stereotactic body radiotherapy.

• 出版日期2017-8