Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides

作者：de Oliveira Penido Marcus Luiz; Zech Coelho Paulo Marcos; de Mello Romulo Teixeira; Pilo Veloso Dorila; de Oliveira Monica Cristina; Kusel John Robert; Nelson David Lee^*

来源：Acta Tropica, 2008, 108(2-3): 249-255.

DOI：10.1016/j.actatropica.2008.10.005

• Schistosomicides
• Aminoalkanethiols
• Aminoalkanethiosulfates
• Aminoalkyl disulfides
• Schistosoma mansoni
• Nanoemulsion
• In vitro studies
• In vivo studies

This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the host animal, the aminoalkanethiosulfuric acids have a low toxicity and a high specificity for the adult female S. mansoni worms. In vitro studies with schistosomula, lung-phase schistosomula and adult worms have demonstrated effects on the tegument and the metabolism on these different stages of S. mansoni worms. The encapsulation of these drugs in a nanoemulsion has resulted in an increase in the in vitro activity.

• 出版日期2008-12
• 单位河北医科大学