A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo

作者：Wang Yinan; Cui Xueling; Tai Guixiang; Ge Jingyan; Li Nan; Chen Fangfang; Yu Fang; Liu Zhonghui^*

来源：Cellular and Molecular Immunology, 2009, 6(5): 387-392.

DOI：10.1038/cmi.2009.50

• activin A
• macrophage
• maturation
• CD68
• CD14

Activin A, a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily, is mainly produced by microglia and macrophages, and its anti-inflammatory and pro-inflammatory activities are both related to macrophage functions. However the direct effect of activin A on the rest macrophages in vivo remains unclear. In the present study, the results showed that activin A not only increased NO and IL-1 beta release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC I and MHC II expression. Moreover, we found that activin A significantly upregulated the expressions of CD14 and CD68, markers of mature macrophages, on the surface of macrophages in vitro and in vivo. These data suggest that activin A can induce primary macrophage maturation in vitro and in vivo, but may not trigger the acquired immune response via regulating expression of MHC molecules involved in presentation of antigen. Cellular & Molecular Immunology. 2009;6(5):387-392.

• 单位
  吉林大学