Accumulation of Plasmid-Mediated Fluoroquinolone Resistance Genes, qepA and qnrS1, in Enterobacter aerogenes Co-producing RmtB and Class A beta-lactamase LAP-1

作者：Park Yeon Joon^*; Yu Jin Kyung; Kim Sang Il; Lee Kyungwon; Arakawa Yoshichika

来源：Annals of Clinical and Laboratory Science, 2009, 39(1): 55-59.

• qepA
• qnrS1
• rmtB
• bla(LAP-1)
• ISCR3C
• gene co-transferance

A new plasmid-mediated fluoroquinolone efflux pump gene, qepA, is known to be associated with the rmtB gene, which confers high-level resistance to aminoglycosides. We investigated the qepA gene in 573 AmpC-producing Enterobacteriaceae including one Citrobacter freundii known to harbor rmtB. Of them, two clonally Unrelated. E. aerogenes harbored qepA. Both isolates co-harbored rmtB, qnrS1, qepA, and bla(LAP-1) on an IncFI type plasmid. The qepA was flanked by two copies of IS26containing ISCR3C, tnPA, tnpR, bla(TEM), and rmtB. The qnrS1 and bla(LAP-1) were located upstream of qepA. All the resistance determinants (qepA, qnrS1, rmtB, and bla(LAP-1)) were co-transferred to E. coli J53 by filter mating from both isolates. Although the prevalence of qepA is currently low, considering the presence of ISCR3C and the possibility of co-selection and co-transferability of plasmids, more active surveillance for these multidrug resistant bacteria and prudent use of antimicrobials are needed.

• 出版日期2009