Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

作者：Schoot Reineke A; Slater Olga; Ronckers Cecile M; Zwinderman Aeilko H; Balm Alfons J M; Hartley Benjamin; van den Brekel Michiel W; Gupta Sanjeev; Saeed Peerooz; Gajdosova Eva; Pieters Bradley R; Gaze Mark N; Mandeville Henry C; Fajardo Raquel Davila; Chang Yen Ch'ing; Gains Jennifer E; Strackee Simon D; Dunaway David; Abela Christopher; Mason Carol; Smeele Ludi E; Chisholm Julia C; Levitt Gill A; Kremer Leontien C M; Grootenhuis Martha A

来源：European Journal of Cancer, 2015, 51(11): 1424-1434.

DOI：10.1016/j.ejca.2015.02.010

• Rhabdomyosarcoma
• Head and neck
• Adverse events
• Radiotherapy
• Brachytherapy
• Quality of life
• Paediatric oncology

Background: Radiotherapy is a well-known cause of adverse events (AEs). To reduce AEs, an innovative local treatment was developed in Amsterdam: Ablative surgery, MOuld brachytherapy and surgical REconstruction (AMORE). Aims: (1) to determine the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors treated with the international standard: external beam radiotherapy (EBRT-based: London) and survivors treated with AMORE if feasible, otherwise EBRT (AMORE-based: Amsterdam).
Methods: All HNRMS survivors, treated in London or Amsterdam between January 1990 and December 2010 (n = 153), and alive >= 2 years post-treatment were eligible (n = 113). A predefined list of AEs was assessed in a multidisciplinary clinic and graded according to the Common Terminology Criteria for Adverse Events.
Results: Eighty HNRMS survivors attended the clinic (median follow-up 10.5 years); 63% experienced >= 1 severe or disabling event, and 76% had >= 5 AEs (any grade). Survivors with EBRT-based treatment were, after adjustment for site, age at diagnosis, and follow-up duration, at increased risk to develop any grade 3/4 event or >= 5 AEs (any grade) compared with survivors with AMORE-based treatments (p = 0.032 and 0.01, respectively). Five year overall survival (source population) after EBRT-based treatment was 75.0%, after AMORE-based treatment 76.9%, p = 0.56.
Conclusion: This study may serve as a baseline inventory and can be used in future studies for prospective assessments of AEs following the introduction of novel local treatment modalities. AMORE-based local treatment resulted in similar overall survival and a reduction of AEs secondary to local treatment.

• 出版日期2015-7