The Role of TLR4, TNF- and IL-1 in Type 2 Diabetes Mellitus Development within a North Indian Population

作者：Doody Natalie E^*; Dowejko Monika M; Akam Elizabeth C; Cox Nick J; Bhatti Jasvinder S; Singh Puneetpal; Mastana Sarabjit S^*

来源：Annals of Human Genetics, 2017, 81(4): 141-146.

DOI：10.1111/ahg.12197

• Type 2 diabetes mellitus
• TLR4 896
• TNF--308
• IL-1-511
• Inflammatory gene polymorphisms
• North Indian population

This study investigated the role of IL-1-511 (rs16944), TLR4-896 (rs4986790) and TNF--308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL-1-511, TLR4-896 and TNF--308 loci. The C allele of IL-1-511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this study, we have demonstrated a conclusive association with IL-1-511 locus and IL-1-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.

• 出版日期2017-7