Acquisition of a Transposon Encoding Extended-Spectrum beta-Lactamase SHV-12 by Pseudomonas aeruginosa Isolates during the Clinical Course of a Burn Patient

作者：Uemura Shuji^*; Yokota Shin ichi; Mizuno Hirotoshi; Sakawaki Eiji; Sawamoto Keigo; Maekawa Kunihiko; Tanno Katsutoshi; Mori Kazuhisa; Asai Yasufumi; Fujii Nobuhiro

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(9): 3956-3959.

DOI：10.1128/AAC.00110-10

Three of seven clonally related Pseudomonas aeruginosa strains isolated from a burn patient produced the extended-spectrum beta-lactamase (ESBL) SHV-12. Its gene was flanked by two IS26 elements with a large transposon (>24 kb). The transposon also contained at least five IS26 elements and a gene encoding the amikacin resistance determinant aminoglycoside 6'-N-acetyltransferase type Ib [aac(6')-Ib]. It was inserted into the gene PA5317 in the P. aeruginosa chromosome.

• 出版日期2010-9