Body size and risk for colorectal cancers showing BRAF mutations or microsatellite instability: a pooled analysis

作者：Hughes Laura A E; Williamson Elizabeth J; van Engeland Manon; Jenkins Mark A; Giles Graham G; Hopper John L; Southey Melissa C; Young Joanne P; Buchanan Daniel D; Walsh Michael D; van den Brandt Piet A; Goldbohm R Alexandra; Weijenberg Matty P^*; English Dallas R

来源：International Journal of Epidemiology, 2012, 41(4): 1060-1072.

DOI：10.1093/ije/dys055

• Colorectal neoplasms
• BRAF
• microsatellite instability
• body mass index
• waist circumference
• height
• cohort study

Background How body size influences risk of molecular subtypes of colorectal cancer ( CRC) is unclear. We investigated whether measures of anthropometry differentially influence risk of tumours according to BRAF c. 1799T4A p. V600E mutation ( BRAF) and microsatellite instability ( MSI) status. %26lt;br%26gt;Methods Data from The Netherlands Cohort Study (n = 120 852) and Melbourne Collaborative Cohort Study (n = 40 514) were pooled and included 734 and 717 colorectal cancer cases from each study, respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) for body mass index (BMI), waist measurement and height were calculated and compared for subtypes defined by BRAF mutation and MSI status, measured from archival tissue. %26lt;br%26gt;Results Results were consistent between studies. When pooled, BMI modelled in 5 kg/m(2) increments was positively associated with BRAF wild-type (HR: 1.16, 95% CI: 1.08-1.26) and MS-stable tumours (HR: 1.15, 95% CI: 1.06-1.24). Waist measurement was also associated with BRAF wild-type (highest vs lowest quartile, HR: 1.59, 95% CI: 1.33-1.90) and MS-stable tumours (highest vs lowest quartile HR: 1.68, 95% CI: 1.31-2.15). The HRs for BRAF mutation tumours and MSI tumours were smaller and non-significant, but differences between the HRs by tumour subtypes were not significant. Height, modelled per 5-cm increase, was positively associated with BRAF wild-type and BRAF mutation tumours, but the HR was greater for tumours with a BRAF mutation than BRAF wild-type (HR: 1.23, 95% CI: 1.11-1.37, P-heterogeneity = 0.03). Similar associations were observed with respect to height and MSI tumours (HR: 1.26, 95% CI: 1.13-1.40, P-heterogeneity = 0.02). %26lt;br%26gt;Conclusions Generally, overweight increases the risk of CRC. Taller individuals have an increased risk of developing a tumour with a BRAF mutation or MSI.

• 出版日期2012-8
• 单位河北医科大学