A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient

作者：Sun H Y; Shields R K; Cacciarelli T V; Muder R R; Singh N^*

来源：Transplant Infectious Disease, 2010, 12(6): 555-560.

DOI：10.1111/j.1399-3062.2010.00543.x

• multidrug resistant
• Pseudomonas aeruginosa
• liver transplant
• biliary cast syndrome
• combination regimen

P>Both bacteremia and biliary cast syndrome are serious post-transplant complications in liver transplant recipients. In the setting of increasing drug resistance in the current era, management of infections caused by multidrug-resistant (MDR) bacteria has proven challenging. We present a case of a liver transplant recipient who developed biliary cast syndrome and intractable MDR Pseudomonas bacteremia that failed to resolve with conventional antimicrobial therapy and which was finally controlled by a novel combination regimen of colistimethate, doripenem, and tobramycin. Future studies validating the clinical efficacy of this combination strategy are warranted.

• 出版日期2010-12