科研之友
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摘要
Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, beta-limit dextrin and pre-gelatinised starch. Methods. The constituent alpha-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions of the alpha-glucans. Physical properties of the wafers were evaluated using texture analysis, dissolution coupled to photography and scanning electron microscopy (SEM). Results. The results highlighted how the beta-limit dextrins chemical and physical properties were ideally suited for the production of buccal delivery wafers. Dissolution testing confirmed the excellent hydration profile of the beta-limit dextrin (within wafers) with time. Using SEM it was evident that the homogeneous %26quot;bee-hive%26quot; like structure of the beta-limit dextrin wafers, unlike the other alpha-glucans, provided a rapidly hydratable strong porous matrix. Conclusions. The beta-limit dextrin alpha-glucan makes a superb (lyophilised) mucoadhesive delivery structure for the delivery of active agents to the buccal mucosa.
- 出版日期2012
