DEHYDROGENATIVE N-HETEROCYCLIZATION OF 2-(2-AMINOARYL)ETHYL ALCOHOLS TO INDOLE DERIVATIVES CATALYZED BY (mu-OXO)TETRARUTHENIUM CLUSTER/1,2-BIS(DIPHENYLPHOSPHINO)BENZENE

作者：Kondo Teruyuki^*; Kanda Takashi; Takagi Daisuke; Wada Kenji; Kimura Yu; Toshimitsu Akio

来源：Heterocycles, 2012, 86(2): 1015-1022.

DOI：10.3987/COM-12-S(N)124

• Ruthenium Catalyst
• Indole Synthesis
• Dehydrogenative N-Heterocyclization

A novel catalyst system of (mu-oxo)tetraruthenium cluster (2) combined with 1,2-bis(diphenylphosphino)benzene (dppbz) realized a simple, selective, and practical synthesis of indole and its derivatives from 2-(2-aminoaryl)ethyl alcohols via dehydrogenative N-heterocyclization reaction. Spontaneous formation of a stoichiometric amount of hydrogen (H-2) was observed, and the present reaction proceeded smoothly under an argon atmosphere without oxidants and/or hydrogen acceptors.

• 出版日期2012-12-31