科研之友
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摘要
Objective: CRP is a most commonly used inflammatory marker with atherosclerotic lesions and during the ischemic event. The reported results of the association of SNPs of CRP gene with ischemic stroke and coronary artery disease are not always consistent. We aimed to examine the association of rs1130864 polymorphism with risk of ischemic stroke and coronary artery disease. Methods: We searched human case-control studies in PubMed, Embase, Google Scholar, China National Knowledge Infrastructure and Wanfang database date to April 2017, then summarized the data and used Odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate risk of ischemic stroke and coronary artery disease. We also performed subgroup analyses, sensitivity analyses and publication bias. Results: A total of 11 eligible articles were analyzed. We found rs1130864 polymorphism was not associated with risk of ischemic stroke in dominant model (OR=0.974, 95% CI=0.873-1.086), recessive model (OR=0.886, 95% CI=0.726-1.082), homozygous model (OR=0.889, 95% CI=0.723-1.094), heterozygous model (OR=0.992, 95% CI=0.885-1.111), and allelic model (OR=0.968, 95% CI=0.891-1.052). No significant association between rs1130864 polymorphism and coronary artery disease risk was observed in dominant model (OR=1.018, 95% CI=0.941-1.102), recessive model (OR=1.035, 95% CI=0.908-1.180), homozygous model (OR=1.040, 95% CI=0907-1.193), heterozygous model (OR=1.016, 95% CI=0.935-1.104), and allelic model (OR=1.007, 95% CI=0.947-1.070). Subgroup analysis suggested no relationship between rs1130864 polymorphism and ischemic stroke and coronary artery disease risk was found either in Asian or Caucasian population. Conclusions: This meta-analysis indicated that the CRP gene rs1130864 variant examined may not modulate ischemic stroke and coronary artery disease risk. However, further studies with larger sample sizes and gene-gene interactions as well as gene-environment interactions are warranted.
