A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome

作者：Cox James^*; Williams Sarah; Grove Kevin; Lane Robert H; Aagaard Tillery Kjersti M

来源：American Journal of Obstetrics and Gynecology, 2009, 201(3): 281.e1.

DOI：10.1016/j.ajog.2009.06.041

• epigenetics
• fetal programming
• metabolomics
• nutrition
• obesity
• pregnancy

OBJECTIVE: To characterize the serum metabolome of a primate model of in utero high-fat exposure
STUDY DESIGN: Serum from maternal and fetal (e130) macaque monkeys exposed to either a high-fat or control diet were analyzed by gas chromalography-mass spectrometry Multivariate data analysis was performed to reduce the generated data set Candidate metabolites were further analyzed for significance by using the analysis of variance and comparative t tests
RESULTS: Approximately 1300 chromatographic features were detected Through multivariate data analysis this number was reduced to 60 possible metabolites With the use of comparative t tests, 22 metabolites had statistical significance (P < 05) over the entire study By virtue of maternal high-fat diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (F < 05)
CONCLUSION: In utero high-fat diet exposure is associated with an altered fetal epigenome and parlays a characteristic modification in the fetal metabolite profile

• 出版日期2009-9