Antibody Persistence and Immune Memory 4 Years Post-Vaccination With Combined Hepatitis A and B Vaccine in Adults Aged Over 40 Years

作者：Chlibek Roman^*; von Sonnenburg Frank; Van Damme Pierre; Smetana Jan; Tichy Petr; Gunapalaiah Bhavyashree; Leyssen Maarten; Jacquet Jeanne Marie

来源：Journal of Travel Medicine, 2011, 18(2): 145-148.

DOI：10.1111/j.1708-8305.2010.00499.x

Persistence of immune response was assessed in adults aged > 40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.

• 出版日期2011-4