Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons

作者：Inoue Y; Honkura N; Kato A; Ogawa S; Udo H; Inokuchi K; Sugiyama H^*

来源：Neuroscience Letters, 2004, 354(2): 143-147.

DOI：10.1016/j.neulet.2003.09.082

• long-term potentiation
• brain derived neurotrophic factor
• F-actin
• Homer
• Vesl

In cultured rat hippocampal neurons, overexpression of Homer1a/Ves1-1S, an inducible protein upregulated by seizure or long-term potentiation, caused a reduction of punctate distribution of a postsynaptic protein Homer1c/Ves1-1L, without significant decrease in its total amount. Clusters of F-actin were also decreased. Treatments of cells with BDNF or a proteasome, inhibitor, which cause increase in the expression level of endogenous Homer1a, also resulted in the reduction of Homer1c puncta. These results indicate that the accumulation of Homer1a, either exogenously expressed or endogenously induced, caused redistribution and dispersion of postsynaptic clusters of Homer1c and F-actin, suggesting an important role of Homer1a in synaptic remodeling.

• 出版日期2004-1-9